Ok this is just down right cool. If you played and loved any of the video game versions of Guitar Hero or Rock Band over the past few years, then get ready to be blown away. The new Rocksmith game allows you to play using ANY REAL GUITAR. The game is for Xbox 360 and Playstation 3. It includes a 1/4 inch to USB cable with the game so that you can plug your guitar directly into the game console.
This game has the fun factor of a video game, but it does really teach you how to play guitar — on a REAL guitar. In addition to the 50 songs that you can learn and play along with, there are also “mini-games” within the game that help to re-enforce guitar player skills such as scales, harmonics, etc.
This game is great for beginners who have never played guitar before all the way up to advanced players. No one is promising that you will become a all star guitar player over night here, but if you want to learn and improve your skills, this is sure a fun way to go about it.
Check out this video which is the video games official launch video.
The top pick based on amazon customer reviews is 
which is available on Nintendo Wii and Nintendo DS(i). This popular and highly rated game was just released in October 2009 in anticipation of the 2010 Winter Games. 
For the Xbox 360 or Playstation 3 is the 
This game is not getting as many positive ratings from amazon customers as the 
and 
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includes more than 40 songs by the Fab Four. You can sing harmonies, play the drums, bass and guitar to your favorite 
in a variety of venues such as The Ed Sullivan Theater, Shea Stadium, Abbey Road and more.